ABSTRACT
Objective. To evaluate maternal and perinatal outcome of women with COVID-19 infection, according to vaccination status. Materials and Methods. This was an observational retrospective study of pregnant women with COVID-19 infection who were referred to our center. Women were asked about their vaccination status, and those who had received a COVID-19 vaccination (at least one dose) were compared with those who had not (no dose at all). The primary outcome was preterm birth at less than 37 weeks of gestation. Results. 120 women with COVID-19 infection were included in the study. 57 had no vaccination (control group);13 had received one dose of vaccine;28 had received two doses;and 22 had received three doses. Preterm birth at less than 37 weeks occurred in 27% of the control group and in 11% in the group of women who had received at least one dose. Also the rates of pregnancy induced hypertension and admission to neonatal intensive care unit were significantly lower. Conclusions. Women with a completed vaccination course and COVID-19 infection have better outcomes compared to those without vaccination.
ABSTRACT
OBJECTIVE: We aimed to assess the correlation between LUS Soldati proposed score and clinical presentation, course of disease and the possible need of ventilation support/intensive care. PATIENTS AND METHODS: All consecutive patients with laboratory confirmed SARS-CoV-2 infection and hospitalized in two COVID Centers were enrolled. All patients performed blood gas analysis and lung ultrasound (LUS) at admission. The LUS acquisition was based on standard sequence of 14 peculiar anatomic landmarks with a score between 0-3 based on impairment of LUS picture. Total score was computed with their sum with a total score ranging 0 to 42, according to Soldati LUS score. We evaluated the course of hospitalization until either discharge or death, the ventilatory support and the transition in intensive care if needed. RESULTS: One hundred and fifty-six patients were included in the final analysis. Most of patients presented moderate-to-severe respiratory failure (FiO2 <20%, PaO2 <60 mmHg) and consequent recommendation to invasive mechanic ventilation (CPAP/NIV/OTI). The median ultrasound thoracic score was 28 (IQR 18-36) and most of patients could be ascertained either in a score 2 (40%) or score 3 pictures (24.4%). The bivariate correlation analysis displayed statistically significant and high positive correlations between the LUS score and the following parameters: ventilation (rho=0.481, p<0.001), lactates (rho=0.464, p<0.001), dyspnea (rho=0.398, p=0.001) mortality (rho=0.410, p=0.001). Conversely, P/F (rho= -0.663, p<0.001), pH (rho = -0.363, p=0.003) and pO2 (rho = -0.400 p=0.001) displayed significant negative correlations. CONCLUSIONS: LUS score improve the workflow and provide an optimal management both in early diagnosis and prognosis of COVID-19 related lung pathology.